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Opt Out of CookiesAutomating Hydrogen Deuterium Exchange MS since 2002
What do we do?
We offer training and consultancy services in the field of Hydrogen Deuterium Exchange Mass Spectrometry (HDX-MS) technology; sharing over seventeen years experience of system development and operation, troubleshooting and commercial data production.
Whether you are just getting started in the field of HDX, or if you have a system in place already, we can help you save time in development, troubleshooting or day to day operations. If your need is hands on development, training system operators or integration, we have a wealth of experience to share.
We apply our experience in automated sample handling, temperature control, column and reagent selection to successfully operate LC systems and rapid non-tryptic proteolysis in a sustained 0 °C environment. When combined with our practical experience in MS source optimization and developing analytical methods for optimal HDX conditions, we can help maximize the efficiency of your HDX system and avoid problems before they arise.
We can help resolve common problems in HDX-MS operation including;
System Contamination - Reduce sample noise, improve data quality
Sample Handling Issues - Get control of your sample, better exchange and quench conditions
Digestion Efficiency - Improve sequence coverage, get better results, faster
Temperature Control - Take care of your sample, get repeatable exchange times
Stabilizing Exchange Time - Get highly reproducible results
Improving Chromatography - Reduce time needed for data interpretation
Reducing Back Exchange - Fewer repeat samples, better data and higher throughput
Why ask us for help?
Current 'off the shelf' packages and applications for HDX-MS work might not necessarily have all the answers. We have worked to build the only fully functional 'start to finish' HDX-MS systems that were used by the only commercial entity offering HDX services at the time.
With 17 years experience in designing, setting up and running modular HDX-MS systems: Whether you need 'from scratch' development, integration with existing systems, training or troubleshooting operations and techniques, we can help.
Let us work with you to get started, streamline your process and achieve outstanding results or just offer a little help in the right direction. Get in touch today, and we can get the conversation going!
We offer a range of HDX-MS training and consultancy services including;
Specific application help is available for;
Epitope Mapping – to identify linear and discontinuous epitopes or paratopes
Protein-Protein Interactions – compare the dynamic differences between wild type and mutant types
Protein Ligand Analysis – identification of protein-ligand binding sites, useful in small or large molecule drug development
Comparability Studies – important in batch to batch or lot to lot production, HDX can be used to Examine higher order structure to confirm or deny structural similarity
How much does it all cost?
Our pricing is dependent upon your need; whether you need a little help in the right direction, you need us to get your system working, you have staff to train or you want technical insight or development.
Perhaps the better question is how much time can we save you.
What do we do?
We offer training and consultancy services in the field of Hydrogen Deuterium Exchange Mass Spectrometry (HDX-MS) technology; sharing over seventeen years experience of system development and operation, troubleshooting and commercial data production.
Whether you are just getting started in the field of HDX, or if you have a system in place already, we can help you save time in development, troubleshooting or day to day operations. If your need is hands on development, training system operators or integration, we have a wealth of experience to share.
We apply our experience in automated sample handling, temperature control, column and reagent selection to successfully operate LC systems and rapid non-tryptic proteolysis in a sustained 0 °C environment. When combined with our practical experience in MS source optimization and developing analytical methods for optimal HDX conditions, we can help maximize the efficiency of your HDX system and avoid problems before they arise.
We can help resolve common problems in HDX-MS operation including;
System Contamination - Reduce sample noise, improve data quality
Sample Handling Issues - Get control of your sample, better exchange and quench conditions
Digestion Efficiency - Improve sequence coverage, get better results, faster
Temperature Control - Take care of your sample, get repeatable exchange times
Stabilizing Exchange Time - Get highly reproducible results
Improving Chromatography - Reduce time needed for data interpretation
Reducing Back Exchange - Fewer repeat samples, better data and higher throughput
Why ask us for help?
Current 'off the shelf' packages and applications for HDX-MS work might not necessarily have all the answers. We have worked to build the only fully functional 'start to finish' HDX-MS systems that were used by the only commercial entity offering HDX services at the time.
With 17 years experience in designing, setting up and running modular HDX-MS systems: Whether you need 'from scratch' development, integration with existing systems, training or troubleshooting operations and techniques, we can help.
Let us work with you to get started, streamline your process and achieve outstanding results or just offer a little help in the right direction. Get in touch today, and we can get the conversation going!
We offer a range of HDX-MS training and consultancy services including;
- Training in the operation of HDX-MS equipment and procedures
- System and Process Troubleshooting
- Automation of HDX Processes
- System Design & implementation
- Fluidics Design & implementation
- Selection of Consumables & Applications
- Custom Temperature Control Design & Manufacture
- Experimental Design
- HDX-MS System installation and integration
- Setup and management of HDX-MS lab systems
Specific application help is available for;
Epitope Mapping – to identify linear and discontinuous epitopes or paratopes
Protein-Protein Interactions – compare the dynamic differences between wild type and mutant types
Protein Ligand Analysis – identification of protein-ligand binding sites, useful in small or large molecule drug development
Comparability Studies – important in batch to batch or lot to lot production, HDX can be used to Examine higher order structure to confirm or deny structural similarity
How much does it all cost?
Our pricing is dependent upon your need; whether you need a little help in the right direction, you need us to get your system working, you have staff to train or you want technical insight or development.
Perhaps the better question is how much time can we save you.